Association between mitochondria-related genes and systemic lupus erythematosus: Findings from Mendelian randomization study.

ABSTRACT: Systemic lupus erythematosus (SLE) is a severe autoimmune disease that damages various organs of the body. Mitochondrial dysfunction is closely related to the pathogenesis of SLE, but the genetic pathophysiological mechanism underlying this association has not been fully elucidated. The current study aims to elucidate the relationships between mitochondria-related genes and SLE via Mendelian randomization analysis. The genetic association data for SLE were obtained from the IEU OPEN GWAS, comprising 7071,163 SNPs from 5201 cases and 9066 controls of European ancestry. Known mitochondrial-related genes in humans were obtained from the MitoCarta 3.0 database. Summary-level data on the methylation, expression, and protein abundance of mitochondria-related genes were obtained from studies of t

SUBMITTER: Huang X 

PROVIDER: S-EPMC12582722 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature