Identification of pancreatic subtypes and prognostic markers on the basis of changes in immunologic signature gene sets activity.

ABSTRACT: The heterogeneity of pancreatic adenocarcinoma (PAAD) tumors is complex. The purpose of this work was to use immunologic signature gene sets (ISGS) activity alterations to identify subtypes of PAAD and to develop valid prognostic indicators. We discovered tumor-related differentially expressed gene sets and their associated subtypes by analyzing changes in ISGS activity via the cancer genome Atlas and the genotype-tissue expression datasets. To evaluate the relationship between these subtypes and clinical characteristics, the immunological microenvironment, and tumor immune dysfunction and exclusion, we conducted survival studies. Furthermore, we identified subtype-specific gene sets and developed a prognostic risk score (RS) model and a corresponding nomogram. The robustness and generaliz

SUBMITTER: Fang J 

PROVIDER: S-EPMC12582723 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature