Genetic evidence of dietary patterns and diet-derived antioxidants on polyp development through gut microbiota modulation.

ABSTRACT: Previous studies have shown that dietary habits are associated with the development of several diseases in humans. However, whether these factors contribute to polyps remains unknown. In this study, we employ Mendelian randomization (MR) to investigate the causal relationship between genetically predicted dietary factors, including diet-derived antioxidant intake, and 4 types of polyps: nasal polyps, female genital tract polyps, colorectal polyps, and gastric polyps, as well as to explore the mediating role of the gut microbiota. We identified genetic variants associated with 7 dietary sources of circulating antioxidants and 15 dietary intake-related factors using genome-wide association study data from the UK Biobank. Genome-wide association study data for the 4 polyp types were obtained

SUBMITTER: Zou Y 

PROVIDER: S-EPMC12582728 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature