Causal association between neutrophil extracellular traps and rheumatoid arthritis: A 2-sample bidirectional Mendelian randomization study.

ABSTRACT: This study explores the causal association between neutrophil extracellular traps and rheumatoid arthritis (RA). A 2-sample bidirectional Mendelian randomization (MR) analysis was performed. The primary analyses were performed using the inverse variance weighted method, with confirmation using the weighted median, weighted mode, and MR-Egger methods. Heterogeneity was detected using Cochran's Q-test, pleiotropy using MR-Egger regression, and outliers using Mendelian randomization pleiotropy residual sum and outlier. The leave-one-out method was used to determine whether a single single-nucleotide polymorphism drove the results. Using RA as the outcome, a causal link emerged between neutrophil count and RA. Notably, substantial heterogeneity and the detection of outliers for neutrophil coun

SUBMITTER: Luo J 

PROVIDER: S-EPMC12582744 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature