Bidirectional Mendelian randomization analysis reveals no causal association between Helicobacter pylori infection and osteoporosis risk.

ABSTRACT: Despite the widespread controversy surrounding the existence of a causal link between contracting Helicobacter pylori (H pylori) and the risk of osteoporosis (OP), this study aimed to ascertain this link using bidirectional two-sample Mendelian randomization (MR) analysis powered by genome-wide association data. Various analysis methods were used, including the inverse variance-weighted (IVW) method, weighted model, simple model, MR-Egger regression, and the weighted median method. The MR-Egger regression intercept term, MR-PRESSO, Cochran Q test, and leave-one-out cross-validation technique were used for sensitivity analysis. The IVW method of two-sample MR showed no causal relationship with anti-H pylori IgG seropositivity and OP (OR: 1.03; 95% CI: 0.90-1.18; P = .69), and the level of H

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12582754 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature