Plasma proteins and rheumatoid arthritis: A Mendelian randomization analysis.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic, progressive inflammatory systemic autoimmune disease with incompletely understood etiology, causing substantial global disease burden. This study aimed to identify plasma proteins associated with RA using Mendelian randomization (MR) of large-scale plasma proteomics, providing potential biomarkers and therapeutic targets for early diagnosis and personalized treatment. We conducted a large-scale plasma proteome MR study using genetic data from 58,293 Europeans (14,361 RA patients and 43,932 controls) in a genome-wide association study. Plasma protein quantitative trait loci data for 4907 adaptors in 35,559 Icelanders were obtained from Ferkingstad et al. (2021). MR methods included MR-Egger, weighted median, inverse-variance weighting, Wald ratio, sim

SUBMITTER: Lu C 

PROVIDER: S-EPMC12582758 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature