Causal effects of dietary antioxidants on epigenetic age: A two-sample Mendelian randomization study.

ABSTRACT: Oxidative stress is one of the leading causes of aging and aging-related diseases. However, there is no conclusive evidence on whether dietary antioxidants can decelerate epigenetic age in human. A two-sample Mendelian randomization (MR) analysis was conducted to explore the causal associations between dietary antioxidants intake and epigenetic age. Summary-level data about 4 dietary antioxidants (vitamin A, vitamin C, vitamin E and carotene) and 4 epigenetic age measures (HannumAge, Intrinsic epigenetic age acceleration [IEAA], GrimAge and PhenoAge) were respectively got from FinnGen Project Database and a meta-analysis of 28 genome-wide association studies (GWAS) involving 34,710 European participants. Inverse variance weighted (IVW) was used as the main method to evaluate causal estimat

SUBMITTER: Huang C 

PROVIDER: S-EPMC12582759 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature