Mendelian randomization reveals the causal links between miRNAs and rheumatoid arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and progressive structural damage, with early diagnosis remaining a significant clinical challenge. Circulating microRNAs (miRNAs) have emerged as promising biomarkers for disease diagnosis, prognosis, and therapeutic response due to their critical roles in gene regulation. However, the specific miRNAs causally involved in RA pathogenesis remain largely unidentified. We conducted a 2-sample Mendelian randomization (MR) analysis using summary-level data from the largest available genome-wide association study of circulating cis-miRNA expression quantitative trait loci (cis-miR-eQTLs) and RA genome-wide association study summary statistics. The inverse variance weighted method served as t

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12582772 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature