Bidirectional Mendelian randomization and cross-sectional study reveal depression as a causal risk factor for endometriosis.

ABSTRACT: Endometriosis (EMs) and depression are both common conditions that have a significant negative impact on quality of life. However, it is still unclear about the relationship between them. The study was designed to investigate the phenotypic and causal association between depression and EMs. For its nationally representative sample, comprehensive health data and publicly accessibility, we chose data from the National Health and Nutrition Examination Survey for our observational study section including 1393 participants in 2005 to 2006 year cycle which contains information both on depression assessed by the Patient Health Questionnaire 9 and self-reported EMs. Initially, we conducted logistic regression analysis to evaluate phenotypic association between depression and EMs utilizing extensiv

SUBMITTER: Jiang L 

PROVIDER: S-EPMC12582783 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature