The Clinicopathologic Spectrum of Rosai-Dorfman-Destombes Disease in Adults: An Analysis of 16 Cases.

ABSTRACT: Rosai-Dorfman-Destombes disease (RDD) is a rare histiocytic proliferation with protean clinical manifestations, resulting from the accumulation of activated histiocytes within nodal and extra-nodal tissues. The diagnosis can be missed, particularly when biopsies are obtained from extra-nodal sites, where histological features may be less specific than those observed in nodal specimens. Here, we examined a case series of 16 adults diagnosed with RDD from Vancouver, Canada between 2015 and 2025. Cases were classified as diagnostically challenging if the time to a definitive pathologic diagnosis exceeded 60 days from the initial biopsy for RDD-related clinical symptoms and > 1 pathologic sampling was required to establish a diagnosis. Eight of 16 patients (50%) were classified as having diagn

SUBMITTER: Trinder M 

PROVIDER: S-EPMC12582906 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature