A Case of Pancreatic Neuroendocrine Tumor Growing Intraductal Extension toward the Main Pancreatic Duct Complicated by Thrombocytopenia: Diagnostic Challenges and Management Strategy.

ABSTRACT: We present a rare and diagnostically challenging case of a pancreatic neuroendocrine tumor (pNET) with intraductal growth into the main pancreatic duct (MPD), complicated by severe thrombocytopenia due to myelodysplastic syndrome. A 37-year-old male presented with thrombocytopenia. Abdominal imaging revealed an 11-mm hypervascular lesion obstructing the MPD in the pancreatic body. The initial serial pancreatic juice aspiration cytological examination (SPACE) demonstrated Class II cytology. Eight months later, the second SPACE revealed Class V cytology. Pancreaticoduodenectomy confirmed pNET G2 with clear intraductal extension. In the postoperative specimen, a portion of the tumor was exposed within the MPD, suggesting Class V cytology. pNETs with intraductal extension (I-pNETs) are rare, a

SUBMITTER: Soga K 

PROVIDER: S-EPMC12582909 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature