MFSD12 promotes proliferation, metastasis and invasion of hepatocellular carcinoma cells and its potential correlation with HAVCR2/LGALS9 immune checkpoint axis.

ABSTRACT:

Background

Major Facilitator Superfamily Domain-containing 12 (MFSD12) has emerged as a critical transmembrane protein with increasingly recognized roles in various cancers. The complex pathogenesis and therapeutic resistance of liver hepatocellular carcinoma (LIHC) present significant clinical challenges. This study investigates MFSD12's potential involvement in LIHC progression.

Methods and results

We performed an extensive pan-cancer analysis of MFSD12 utilizing integrated datasets from The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), and the ArrayExpress database. Our investigation focused on evaluating its prognostic significance, clinical implications, associated signaling pathways, immune cell infiltration, gene mutations, and sensitivity to chemothe

SUBMITTER: Sun K 

PROVIDER: S-EPMC12582970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature