D-Mannose for prevention of recurrent urinary tract infection in adult women: An updated systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

Approximately 50%-60% of adult women experience at least one episode of urinary tract infection (UTI) during their lifetime, with 20%-24% of them experiencing recurrence within a year. Several randomized controlled trials have explored the efficacy and safety of D-mannose for the prevention of UTI in adult women but reported conflicting results.

Objective

We performed a meta-analysis comparing D-mannose with placebo or no treatment for the prevention of UTI in adult women.

Methods

We systematically searched PubMed, Scopus, and Cochrane Central databases for studies comparing D-mannose with placebo or no treatment for the prevention of UTI in adult women. The outcomes of interest were recurrent UTIs during follow-up and adverse events. Heterogeneity was assesse

SUBMITTER: Murali Krishna M 

PROVIDER: S-EPMC12582996 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature