Life-long body mass index trajectories and cardiometabolic biomarkers-the Danish diet, cancer, and health-next generations cohort.

ABSTRACT:

Background/objectives

Higher body mass index (BMI) is strongly associated with cardiovascular metabolic diseases, however, BMI changes across the lifespan may be complex and non-linear. Furthermore, heterogeneous BMI trajectories may exhibit different cardiometabolic traits. We aimed to identify BMI trajectories over up to 50 years and examine their associations with cardiometabolic biomarkers.

Subjects/methods

In total, 30,581 participants from the Danish Diet, Cancer and Health - Next Generations cohort were included in the study. Participants recalled their weight history for each decade through questionnaires. Weight and height were measured, and blood samples were collected during a clinic visit. Cardiometabolic biomarkers (Hemoglobin A1c, total cholesterol, triglycerid

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12583120 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature