Birth weight in relation to maternal and neonatal biomarker concentration of perfluorooctane sulfonic acid: a meta-analysis and meta-regression from a systematic review.

ABSTRACT:

Background

Perfluorooctane sulfonic acid (PFOS) is a legacy chemical, that while banned in some countries, is still found in various environmental media and in nearly all humans given its long half-life.

Objective

We examined mean birth weight (BW) differences in relation to PFOS exposure biomarkers using systematic review methods.

Methods

We fit a random effects model to obtain the overall pooled effect and for stratified analyses examining biomarker sample type and timing, study confidence, scaling factors, and country of study origin. We also conducted a meta-regression to assess the impact of gestational age and other factors on the overall pooled effect.

Results

We found a 30-gram BW deficit (β = -30.3 g; 95%CI: -41.6, -18.9) with each ln-unit PFOS increas

SUBMITTER: Wright JM 

PROVIDER: S-EPMC12583133 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature