Longitudinal and cross-sectional analysis of perfluoroalkyl substances and kidney function.

ABSTRACT:

Background

Perfluoroalkyl substances (PFAS) constitute a diverse group of chemical compounds used in various consumer products. While the associations between PFAS and certain adverse human health effects are well-documented, their impact on kidney function remains less known.

Objective

The main aim of this study is to investigate the relationship between PFAS levels and kidney function (estimated glomerular filtration rate [eGFR]) utilizing a longitudinal design.

Methods

The population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study included 997 individuals at baseline (all aged 70 years, 50% females). Follow-up investigations were performed at 75 and 80 years of age. Seven major PFAS were determined in plasma using ultra-high perf

SUBMITTER: Eklund A 

PROVIDER: S-EPMC12583146 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature