Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer.

ABSTRACT:

Background

The purpose of this study was to use a two-sample Mendelian randomization (MR) approach to explore the causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer (OC).

Methods

By leveraging genome-wide association study (GWAS) data from publicly available databases, we identified single nucleotide polymorphisms (SNPs) representing genetic variants for both hyperthyroidism/thyrotoxicosis and OC. We employed the inverse variance weighted method (IVW) to assess the association between hyperthyroidism/thyrotoxicosis and the risk of OC. Further, we evaluated SNP heterogeneity using the Cochran's Q test and detected the presence of outlier SNPs using the MR-PRESSO test. To examine the pleiotropy of SNPs, we employed the MR-Egger intercept test. Additionally,

SUBMITTER: Wang H 

PROVIDER: S-EPMC12583247 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature