Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a prevalent global malignancy characterized by a high incidence and poor prognosis. Current diagnostic and therapeutic modalities are insufficient to meet the demands for effective HCC diagnosis and management. Cuproptosis represents a novel mechanism of cellular death, which may offer new avenues for drug research in oncology.

Methods

We employed the Summary-data-based Mendelian Randomization (SMR) method alongside gene intersection analyses related to Cuproptosis, identifying SIRT2 as the target gene. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing (stRNA-seq) were conducted to investigate the role of SIRT2 in HCC. Subsequently, we analyzed the differentially expressed genes of SIRT2 + malignant cell

SUBMITTER: Chen C 

PROVIDER: S-EPMC12583258 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature