Congenital Hypothyroidism: Long-Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose.

ABSTRACT:

Objectives

This study aims to review the long-term outcome of congenital hypothyroidism (CH) and whether patient- or treatment-related factors impact the outcomes, especially focusing on the initial Levothyroxine dose.

Methods

This is a retrospective, cross-sectional study of the children diagnosed with CH who received Levothyroxine at Ajou University Hospital between 2003 and 2024. Comparative analysis was performed between the low (<10 mcg/kg) and high (≥10 mcg/kg) initial dose groups. Repeated-measures analysis of covariance was employed to evaluate longitudinal changes in growth outcomes, and multivariate linear regression was utilised to evaluate the effects of clinical factors on the intelligence quotient (IQ).

Results

Among the study population, 84 of 144 child

SUBMITTER: Park JH 

PROVIDER: S-EPMC12583312 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature