Biochemical Diagnosis of Phaeochromocytoma and Paraganglioma in Children and Adolescents: A Retrospective Cohort Study.

ABSTRACT:

Introduction

Currently, it is unclear whether plasma free or 24-h urinary fractionated metanephrines are preferable for diagnosis of phaeochromocytoma/paraganglioma (PPGL) in children.

Objectives

To investigate whether measurements of plasma free and 24-h urinary fractionated metanephrines are reliable tests for screening for PPGL in children.

Methods

This retrospective study included a cohort of 138 paediatric patients (5 to 18 years), 64 with and 74 without PPGL. Data included sex, age, plasma concentrations of free metanephrines, and genetic test results. For a subset of 89 children tested for PPGL, concentrations of 24-h urinary fractionated metanephrines were also available. For patients with PPGL, data also included tumour location, size, catecholamine tumour ph

SUBMITTER: Potthoff K 

PROVIDER: S-EPMC12583316 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature