Tumor microenvironment remodeling across thyroid cancer differentiation states revealed by spatial transcriptomics.

ABSTRACT:

Background

Thyroid cancer is the most common endocrine malignancy, with an increasing incidence, particularly driven by differentiated thyroid cancers (DTC), including papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). Although DTC generally have excellent prognosis, dedifferentiated forms such as poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) exhibit aggressive progression and poor outcomes. Understanding the tumor microenvironment (TME) is crucial for developing novel therapeutic strategies.

Methods

We performed spatial transcriptomics (ST) on formalin-fixed paraffin-embedded (FFPE) tumor tissues from 12 patients with PTC, FTC, PDTC, or ATC using the Visium CytAssist platform. Cell type composition was inferred using

SUBMITTER: Seok J 

PROVIDER: S-EPMC12583360 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature