Fibrinogen beta chain as a prognostic biomarker and therapeutic target in tobacco-associated lung adenocarcinoma.

ABSTRACT: The β-subunit of fibrinogen (FGB), a key element of the main plasma clotting protein, is increasingly recognised as a contributor to tumour biology. To clarify its relevance in smoking-related lung adenocarcinoma (LUAD), we interrogated seven public transcriptomic cohorts obtained from the TCGA portal on UCSC-Xena and from the GEO repository, together with their matched clinical annotations. Across datasets, patients with a history of smoking displayed markedly higher FGB transcript levels than never-smokers. Greater FGB abundance correlated with worse Eastern Cooperative Oncology Group (ECOG) performance status and more advanced TNM classification. Genotype-stratified analysis showed reduced FGB expression in EGFR-mutant LUAD, whereas KRAS- or STK11-mutant tumours exhibited the opposite p

SUBMITTER: Xue J 

PROVIDER: S-EPMC12583432 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature