Decoding immunometabolism with next-generation tools: lessons from dendritic cells and T cells.

ABSTRACT: Cellular metabolism plays a pivotal role in regulating the effector functions and fate decisions of immune cells, shaping immune responses in homeostasis and disease. Metabolic pathways also serve as critical signaling hubs governing immune cell behavior. Deregulated metabolic pathways contribute to immune dysfunction, fueling disease progression and creating challenges for therapeutic interventions. The recent development of advanced technologies to delineate immunometabolic regulation has revolutionized our understanding of immune cell biology. These tools, ranging from quantitative single-cell metabolomics to in vivo spatial tissue profiling and DC-based metabolic therapy, have shifted the focus from broad nutrient pathways to a detailed exploration of metabolic reprogramming within dis

SUBMITTER: Wang YH 

PROVIDER: S-EPMC12583481 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature