Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis.

ABSTRACT: The complex interplay between circulating metabolites and immune responses, which is pivotal to disease pathophysiology, remains poorly understood and understudied in systematic research. Here, we performed a comprehensive analysis of the immune response and circulating metabolome in two Western European cohorts (534 and 324 healthy individuals) and one from sub-Saharan Africa (323 healthy donors). At the metabolic level, our analysis revealed sex-specific differences in the correlation between phosphatidylcholine and cytokine responses following ex vivo stimulation. Notably, sphingomyelin exhibited a significant negative correlation with monocyte-derived cytokine production in response to Staphylococcus aureus stimulation, a finding that was validated through functional experiments. Subse

SUBMITTER: Fu J 

PROVIDER: S-EPMC12583525 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature