The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment.

ABSTRACT: BackgroundMild cognitive impairment (MCI) has been related to impairment in cerebrovascular perfusion and microstructural magnetic resonance imaging (MRI) parameters. However, the relationship between cerebrovascular perfusion and microstructure remains understudied, especially within normal-appearing white matter (NAWM).ObjectiveThis study aimed to investigate the differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition (NC) and MCI using multiple MRI measurements within NAWM.MethodsWe examined differences between 24 MCI and 55 NC participants in NAWM for cerebrovascular perfusion and microstructural measures, including cerebrovascular reactivity (CVR), cerebral blood flow, arterial transit time (ATT), and intracellular volume fr

SUBMITTER: Kim D 

PROVIDER: S-EPMC12583654 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature