Increased autoantibodies against incretin indicate poor prognosis in patients with diabetes.

ABSTRACT: This retrospective cohort study aimed to elucidate the clinical significance of measuring autoantibodies against incretins in diabetes. We enrolled 274 patients with diabetes (mean age ± standard deviation [SD]: 63.1 ± 12.1 years) and 109 healthy controls (mean age: 58.0 ± 5.8 years). Titers of autoantibodies against incretins (glucose-dependent insulinotropic peptide and glucagon-like peptide-1) were measured using an amplified luminescent proximity homogeneous assay-linked immunosorbent assay. Both incretin antibody titers were significantly higher in patients with diabetes than in healthy controls (both P < 0.01). A mean 4.9-year (maximum 10-year) follow-up study revealed that patients who tested positive for glucose-dependent insulinotropic peptide antibodies had significantly worse pr

SUBMITTER: Takemoto M 

PROVIDER: S-EPMC12583695 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature