The Hippo-YAP signaling pathway promotes hepatocellular carcinoma progression by inducing FHL3 expression.

ABSTRACT: The Hippo pathway plays an important role in cell proliferation, differentiation, and cancer occurrence. Yes-associated protein 1 (YAP) is a key effector molecule of Hippo pathway. Previous studies have found abnormal YAP overexpression in many solid tumors, including hepatocellular carcinoma (HCC). Here, we attempt to explore the cancer-promoting mechanism of YAP in HCC. The target gene of Hippo-YAP pathway, Four and a half LIM domain protein 3 (FHL3), was screened by spontaneous hydrodynamic tumor model with YAP participation and two publicly HCC microarray sets. Western blot (WB) and immunohistochemical (IHC) showed high protein levels of FHL3 in tumor tissues and the expression of FHL3 was associated with poorer prognosis. The biological effect experiments showed that FHL3 significantl

SUBMITTER: Rao D 

PROVIDER: S-EPMC12583741 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature