Atypical cadherin CELSR2 acts as a therapeutic target for glioma through WNT3A/β-catenin signaling.

ABSTRACT: Glioma is the most common primary brain tumors and has a high recurrence and mortality rate after surgery. Most gliomas are of astrocytic origin. We recently demonstrated that Celsr2 is essential for injury-induced responses and functions of astrocytes, while its role in the development and treatment of gliomas remains unexplored. In this study, an increase of CELSR2 expression was identified in patient glioma samples and glioma cell lines, and higher levels of CELSR2 correlate with poorer patient survival as indicated by TCGA data. In cultured glioma cells, CELSR2 knockdown reduced proliferation and caused cell cycle arrest, which was further supported by proteomic analysis. CELSR2 knockdown inhibited Wnt/β-catenin signaling, and the effect could be reversed by activating β-catenin using

SUBMITTER: Liu A 

PROVIDER: S-EPMC12583761 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature