Advancing Deuterium MRI to Track Human Cerebral Glucose Metabolism at 7 T: A Comparison of Glucose-d₂ and Glucose-d₇ Ingestion.

ABSTRACT: Deuterium metabolic imaging (DMI) allows non-invasive dynamic in vivo assessment of transport, uptake and metabolism of deuterated molecules. To date, DMI experiments in humans have involved ingestion of glucose-d₂ ([6,6'-²H₂]glucose), where labelling of the sixth carbon facilitates ²H-label transfer to pyruvate, then to lactate (Lac) via lactate dehydrogenase, or to glutamate and glutamine (Glx) via the tricarboxylic acid cycle. There are advantages to using glucose-d₇ ([1,2,3,4,5,6,6'-²H₇]glucose) for DMI as this should yield larger signals from glucose and downstream metabolites, including deuterated water (HDO). Here, we evaluated DMI at 7 T following glucose-d₇ ingestion for monitoring glucose metabolism in the human br

SUBMITTER: Cocking DJ 

PROVIDER: S-EPMC12583885 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature