Druggable Genome Mendelian Randomization and GWAS-sceQTLs MR Analysis Reveal Genetic Associations Between Open-Angle Glaucoma and Immune Cells, and Identify Potential Drugs.

ABSTRACT:

Purpose

The purpose of this study was to identify therapeutic targets and repurposable drugs for primary open-angle glaucoma (POAG) by investigating its immunometabolic mechanisms using druggable genomic and single-cell transcriptomic approaches.

Methods

We integrated druggable genome-wide and single-cell Mendelian randomization (MR) using POAG genome-wide association study (GWAS) data, blood and single-cell expression quantitative trait loci (eQTL) datasets. Causal genes were identified via colocalization and MR inference (inverse-variance weighted [IVW]). Drug-gene interactions were predicted using molecular docking (DSigDB/CB-Dock2), and safety was assessed via phenome-wide association studies (PheWAS).

Results

(1) Identified two POAG causal genes: risk genes YWHAG

SUBMITTER: Ke K 

PROVIDER: S-EPMC12584030 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature