Aldehydes as CO Releasing Molecules: <i>In Situ</i> and <i>Ex Situ</i> Giese Reactions and Palladium-Catalyzed Aminocarbonylations.

ABSTRACT: We report the adoption of a two-chamber reactor making use of aliphatic aldehydes in the role of CO releasing molecules (CORMs). Upon photocatalytic conditions, an acyl radical (RCO^•) was first formed, prone to lose CO. The resulting alkyl radical was employed in the in situ conjugate addition onto a Michael acceptor (in the first chamber), and the released CO was employed in ex situ palladium-catalyzed aminocarbonylations (in the second chamber) to ensure a 100% atom-economical reaction.

SUBMITTER: Cassera E 

PROVIDER: S-EPMC12584138 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature