Scope and Synthetic Applications of the Aryl-Alcohol Oxidase from <i>Streptomyces hiroshimensis</i> (<i>Sh</i>AAO).

ABSTRACT: The sustainable production of carbonyl compounds is of growing interest due to their broad academic and industrial interest. Herein, we explored the aryl-alcohol oxidase from Streptomyces hiroshimensis (ShAAO), mapping its activity across diverse alcohols, revealing a distinct profile from other natural AAOs. Integrated into tandem organocatalytic processes, ShAAO enabled the synthesis of various chiral compounds, including an intermediate for paroxetine. Gram-scale reactions delivered high yields and turnover numbers exceeding 65000. Immobilization further enhanced stability, highlighting ShAAO as an efficient and industrially relevant biocatalyst.

SUBMITTER: Ascaso-Alegre C 

PROVIDER: S-EPMC12584139 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature