Remnant cholesterol, low-density lipoprotein cholesterol and atherosclerotic cardiovascular disease in metabolic dysfunction-associated steatotic liver disease: a cohort study.

ABSTRACT:

Background

Recent studies highlighted the independent role of remnant cholesterol (RC) on the risk of atherosclerotic cardiovascular disease (ASCVD). We explored interrelationships among low-density lipoprotein cholesterol (LDL-C), RC, and ASCVD in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods

Analyzing 25,418 MASLD and 57,501 non-MASLD ASCVD- free Chinese adults from the Kailuan Study (2006-2011), we used Fine-Gray models to evaluate LDL-C and RC associations with ASCVD across varying cut-offs, incorporating China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) 10-year risk.

Results

The MASLD group had comparable LDL-C but elevated RC levels compared to the non-MASLD. In MASLD individuals, associa

SUBMITTER: Zhou D 

PROVIDER: S-EPMC12584210 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature