A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion.

ABSTRACT:

Background

Intra-cerebrospinal fluid (CSF) drug delivery bypasses the blood-brain barrier, making it a promising route of delivery to treat central nervous system (CNS) diseases. Optimizing this delivery route is challenging because of complex interactions among drug kinetics, CSF flow dynamics and anatomical variations. Non-human primate (NHP) models provide an approximation to human physiology, making a suitable surrogate for studying intra-CSF drug dispersion. We present a NHP digital model for pharmacokinetic prediction of intra-CSF solute neuraxial dispersion that incorporates craniospinal compliance and other key physiological features.

Methods

A 3D subject-specific digital model of the NHP CSF system was formulated using a 3D multi-phase computational fluid dynamics (

SUBMITTER: Khani M 

PROVIDER: S-EPMC12584216 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature