Interaction between rasagiline and Pueraria radix in in vitro models of parkinson's disease.

ABSTRACT:

Background

The management of Parkinson's disease (PD) remains challenging owing to the limitations of current therapies. Although rasagiline (RASA), a monoamine oxidase-B (MAO-B) inhibitor, offers advantages over levodopa, its efficacy as a monotherapy is moderate. Pueraria root (PR), a traditional East Asian medicine, has demonstrated neuroprotective potential against several neurodegenerative conditions. This study investigated the pharmacodynamic and pharmacokinetic interactions between RASA and PR to evaluate their potential as a combination therapy for PD.

Methods

We examined synergistic effects on MAO-B inhibition by performing MAO-B enzyme reaction assay. We measured the cell viability for evaluating the neuroprotective effects of their co-administration against 6-OHD

SUBMITTER: Huh E 

PROVIDER: S-EPMC12584229 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature