Signaling pathway of DNA replication and toll-like receptors was inhibited in C6/36 cells infected with Japanese encephalitis virus.

ABSTRACT:

Background

The Aedes albopictus C6/36 cell line is model system for studying mosquito-borne viruses. These cells exhibit high permissiveness to Japanese encephalitis virus (JEV), supporting robust viral replication and producing a significant viral load.

Methods

Given C6/36 cells established susceptibility, this study employed 4D label-free quantitative proteomics to investigate the underlying mechanisms that enable C6/36 cells to be readily cultured and facilitate efficient JEV infection. C6/36 cells were infected with JEV at MOI of 0.5 and harvested at 0,6,12, and 24 hours post-infection (HPI) for 4D label-free quantitative proteomics analysis.

Results

Proteomic data analysis revealed that differentially expressed proteins were primarily involved in signal transduct

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12584240 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature