UHRF1 and NF-κB signaling in prostate cancer progression insights from bioinformatics and experimental validation.

ABSTRACT:

Background

Increasing evidence implicates the NF-κB/p65 signaling pathway in the progression of prostate cancer (PC) and the development of resistance to androgen deprivation therapy. This study aimed to investigate the potential role of UHRF1, a key epigenetic regulator, in modulating NF-κB activity, and to evaluate its association with clinicopathological features and clinical outcomes in PC patients.

Methods

Differentially expressed genes (DEGs) were identified using the GSE104749 dataset. UHRF1 expression was validated across TCGA and GEO cohorts and further confirmed in clinical specimens using Western blotting and immunohistochemistry. Survival outcomes were evaluated using Kaplan-Meier and Cox regression analyses. A prognostic model was built incorporating UHRF1, Glea

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12584322 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature