Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development.

ABSTRACT: Enteroendocrine cells (EECs) are rare intestinal epithelial cells producing multiple hormones that regulate essential aspects of digestion and energy. EEC subtypes, their hormone repertoire and differentiation mechanisms from intestinal stem cells have been characterized in the adult intestine. Although EECs must be functional from birth because their absence leads to severe intestinal malabsorption in newborns, the processes that determine their subtype specification during development remain largely unknown. We used mouse embryos, human pluripotent stem cell-derived intestinal organoid models and single-cell transcriptomics to characterize EEC lineages and dynamics during development. Our findings demonstrate that in both mice and humans, the majority of EECs are specified during develop

SUBMITTER: Jimenez S 

PROVIDER: S-EPMC12584403 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature