Epidemiological, clinical, and molecular characteristics of coxsackievirus A2 infections during a herpangina outbreak in children on an Island in Eastern China in 2024: a surveillance-based study.

ABSTRACT:

Background

Herpangina is an acute pediatric illness caused by enteroviruses, yet the predominant circulating serotype in mainland China has not been well characterized. In this study, Coxsackievirus A2 (CV-A2) emerged as the dominant serotype among herpangina cases in Yuhuan City, Zhejiang Province. These findings underscore the importance of further research into the epidemiological distribution and molecular features of CV-A2 in this region.

Methods

A total of 133 child herpangina cases were included during May and June 2024. Enteroviruses were detected using RT-PCR, followed by serotyping and sequencing. Phylogenetic and recombination analyses were performed to assess genetic diversity and evolutionary relationships.

Results

Among the 133 cases (median age: 3 years

SUBMITTER: Xing B 

PROVIDER: S-EPMC12584420 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature