Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.

ABSTRACT:

Background

Major depressive disorder (MDD) and primary insomnia (PI) share overlapping symptoms and neurobiological features, yet they represent distinct clinical entities. Thus, identifying both shared and disorder-specific structural and functional brain alterations is critical for enhancing our mechanistic understanding and improving diagnostic differentiation between these conditions.

Methods

A comprehensive literature search was conducted in the PubMed, Web of Science, and Embase databases, covering publications up to April 2024. The seed-based d-mapping software was used to investigate common and distinct abnormalities of gray matter volume (GMV) and resting-state amplitude of low-frequency fluctuations (ALFF) between MDD and PI. Meta-regression analysis was employed t

SUBMITTER: Du W 

PROVIDER: S-EPMC12584438 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature