Plasma lipidomics for biomarker identification in non-muscle invasive bladder cancer.

ABSTRACT:

Background

Bladder cancer is a high-incidence malignant tumor in the world. Currently available potential biomarkers lack sufficient diagnostic accuracy, underscoring the need for novel biomarkers. Lipid metabolites have emerged as promising candidates for diagnosing malignant tumors in recent years. Few studies explored the potential value of lipids in bladder cancer. Our study investigated plasma lipid metabolism markers in non-muscle invasive bladder cancer (NMIBC) using liquid chromatography-high resolution mass spectrometry (LC-HRMS).

Methods

Overall, 214 cases were included, with 106 NMIBC patients as NMIBC group and 108 healthy adults as control group. Plasma lipids were profiled using LC-HRMS to distinguish NMIBC group from control group, low-grade NMIBC group from c

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12584469 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature