Immunogenicity and gene polymorphism analysis of Plasmodium ovale wallikeri glycosylphosphatidylinositol-anchored micronemal antigen (GAMA).

ABSTRACT:

Background

The glycosylphosphatidylinositol-anchored micronemal antigen (GAMA) protein is integral to the invasion of erythrocytes by Plasmodium species, with well-documented roles in the merozoite binding of both Plasmodium falciparum and Plasmodium vivax. In the malaria endemic areas infections caused by Plasmodium ovale spp. can escalate to severe malaria, characterized by life-threatening anaemia. Nevertheless, P. ovale spp. have been frequently neglected in the study, and the species-specific P. ovale wallikeri (Pow) GAMA (PowGAMA) protein remains uncharacterized. This study investigates the genetic diversity of P. ovale spp. imported from Africa and evaluates the immunogenicity of recombinant PowGAMA (rPowGAMA).

Methods

The study conducted an analysis of 56 P. ovale is

SUBMITTER: Ling X 

PROVIDER: S-EPMC12584486 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature