Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.

ABSTRACT:

Background

Amoxicillin is among the most frequently prescribed antibiotics globally, either as monotherapy or in combination with clavulanic acid as amoxicillin-clavulanic acid (AMC). However, the prolonged use of AMC and other antibiotics has intensified selection pressure, accelerating the emergence of AMC-resistant and multidrug-resistant (MDR) strains. Klebsiella, a member of the ESKAPE pathogens, employs diverse resistance mechanisms against multiple classes of antibiotics. This study was aimed to identify environmental Klebsiella isolates resistant to AMC with MDR phenotype and to investigate the underlying genetic determinants contributing to their resistance and virulence.

Methodology

Water samples were collected from 14 sites, encompassing both wastewater and natura

SUBMITTER: Ahmed V 

PROVIDER: S-EPMC12584517 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature