Ursolic acid suppresses gastric cancer by targeting the miR-27a-3p/Wnt/β-catenin signaling axis.

ABSTRACT: Gastric cancer (GC) is a common type of cancer known for its challenges in early detection and unfavorable prognosis. The pathway involving Wnt/β-catenin and the improper regulation of microRNAs (miRNAs), especially miR-27a-3p, are crucial in the advancement of GC. Ursolic acid (UA), which is a naturally occurring anticancer agent, shows promise in the inhibition of GC. Although UA's anticancer effects have been recognized, the underlying molecular mechanisms in GC remain incompletely defined. Our findings indicate that UA strongly restricts the expansion, motility, and invasive behavior of GC cells by dampening activity within the Wnt/β-catenin cascade. Treatment with UA lowered miR-27a-3p expression, and blocking this miRNA further curtailed tumor cell aggressiveness by restoring DKK2, w

SUBMITTER: Xiang F 

PROVIDER: S-EPMC12584524 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature