Involvement of formyl peptide receptor 2 in canine coronavirus infection: in vitro and in Silico approaches.

ABSTRACT: Canine coronavirus type II (CCoV-II), an alphacoronavirus, is responsible for mild enteritis, especially in puppies, but due to its plasticity, it can also cause serious diseases in humans. Formyl peptide receptors (FPRs) play an important role in modulating immune responses, and their expression is variably regulated by cell type and by viral infections. In this study, the role of FPR2 during CCoV infection in a canine fibrosarcoma (A72 cells) cell line as well as in a feline Crandell-Rees Feline Kidney (CRFK) cell line was investigated by in vitro and in silico approaches. During infection, in the presence of WRW4, a specific FPR2 inhibitor, a reduction in gene and protein levels of FPR2 in CCoV infected cells was observed. These results were accompanied by worsened changes in cell viabi

SUBMITTER: Giugliano R 

PROVIDER: S-EPMC12584531 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature