NsrM (All0345) and NsrX (Alr1976), two FurC (PerR)-targeted transcriptional regulators, modulate nitrogen metabolism and heterocyst differentiation genes in the cyanobacterium <i>Anabaena</i> sp. strain PCC 7120.

ABSTRACT: The control of nitrogen metabolism in the model cyanobacterium Anabaena sp. strain PCC7120 is a complex process orchestrated by master regulators such as NtcA, HetR, and FurC (PerR). These proteins establish complex networks with secondary regulators, finely tuning cellular metabolism in response to diverse, often undefined environmental signals. The XRE-like Alr1976 and the MerR-like All0345 proteins are two predicted transcriptional regulators regulated by FurC. While All0345 is widespread, both proteins have homologs conserved across several bacterial phyla, with alr1976 often followed by a gene encoding a Zn-metalloprotease. Previous transcriptomic analyses showed that furC overexpression affected alr1976 expression slightly more under nitrogen-deficient con

SUBMITTER: Guio J 

PROVIDER: S-EPMC12584617 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature