Whole-genome sequence characterization of respiratory syncytial virus in the Johns Hopkins Health System during the 2024-2025 respiratory season.

ABSTRACT: Respiratory syncytial virus (RSV) remains a leading cause of lower respiratory tract infections in young children, older adults, and immunocompromised individuals worldwide. In 2023, the first RSV vaccines and the widespread use of monoclonal antibodies were approved, underscoring the need for genomic surveillance to monitor their effectiveness and the emergence of antibody-resistant genotypes. This study details the whole-genome characterization of RSV strains circulating between September and December 2024. Whole RSV genome amplification was performed using overlapping amplicons, followed by Nanopore sequencing. Viral genomes were analyzed to determine subtypes, clade prevalence, and amino acid substitutions. Epidemiological and clinical data were collected to assess associations with sp

SUBMITTER: Zhuang TX 

PROVIDER: S-EPMC12584621 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature