Importance of <i>aggR</i> sequence variants detection for accurate molecular diagnosis of enteroaggregative <i>Escherichia coli</i>.

ABSTRACT: Enteroaggregative Escherichia coli (EAEC) is one of the main diarrhea causative agents. This E. coli pathotype is defined by an aggregative adherence pattern observed in HEp-2 cells. Molecular diagnosis is still a challenge due to EAEC genetic heterogeneity. Different publications described primers for aggR and aatA detection to characterize EAEC. Recently, afpR has been suggested as EAEC molecular marker of some strains, demonstrating the existence of two subpopulations within this pathotype: typical and atypical EAEC, respectively, comprising aatA+/aggR+ and aatA+/afpR+. Studies performed by our group, however, detected conflicting results using different primer pairs for aggR. Therefore, this study mainly aimed to ana

SUBMITTER: Del Carpio AMG 

PROVIDER: S-EPMC12584630 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature