Impact of multiplex polymerase chain reaction testing in patients with bacteremia.

ABSTRACT: Rapid identification of pathogens in bacteremia is critical for optimizing antimicrobial therapy. The FilmArray blood culture identification 2 (BCID2) panel enables multiplex PCR-based detection of pathogens and resistance genes. This study aimed to evaluate the clinical impact of BCID2 implementation in hospitalized patients with bacteremia. To this end, we conducted a retrospective study at a single Japanese center (May 2018-December 2024). The outcomes included length of stay, in-hospital mortality, antimicrobial days of therapy (DOT), and days of antimicrobial spectrum coverage (DASC) score. The pre-BCID2 and BCID2 implementation periods were compared. Among the 2,872 patients with positive blood cultures, BCID2 implementation was associated with a significant reduction in mortality (a

SUBMITTER: Kitagawa D 

PROVIDER: S-EPMC12584631 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature