Integrated multi-omics identifies dysregulated lipid metabolism of paresis in dairy sheep during the early transition period.

ABSTRACT: Paresis during the early transition period is a prevalent metabolic disorder in prolific dairy sheep, characterized by a complex and poorly understood pathogenesis. This study longitudinally monitored a cohort of dairy sheep from 21 days antepartum to 1 day postpartum. During this period, blood, fecal, and colostrum samples were collected. The pathway of paresis was revealed by plasma metabolome and fecal 16S sequencing, and potential early biomarkers were identified. The physiological parameters of healthy dairy sheep (HDS) and paretic dairy sheep (PDS) differed in both the antepartum (not yet paresis) and postpartum (paresis) periods. Elemental analysis revealed higher levels of copper, potassium, and magnesium in PDS colostrum compared to HDS. Metabolomic analysis of HDS and PDS in ante

SUBMITTER: Jiao S 

PROVIDER: S-EPMC12584643 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature